Nov 27, 2008

Science - Gut chemical may inspire new way to fight obesity

Will Dunham

WASHINGTON (Reuters) - Scientists have identified a fatty substance made in the gut that signals the brain when it's time to stop eating -- a discovery that could inspire new approaches to fighting obesity.

Writing in the journal Cell on Wednesday, U.S. researchers said experiments with mice and rats showed that a naturally occurring fat-derived chemical messenger called NAPE regulated how much the animals ate. It is present in people and may do the same thing, they said.

Gerald Shulman of Yale University and the Howard Hughes Medical Institute and colleagues said that when the rodents were fed a fatty meal, their small intestine made a lot of NAPE and put it into the bloodstream. It then traveled to the brain and shut down hunger signals, they said.

NAPE levels shot up after the rodents ate a fatty meal, but not when they ate only protein or carbohydrates, they said.

The researchers then synthesized NAPE and injected it into the abdomen of the animals, whose appetites diminished greatly. When NAPE was delivered in much smaller amounts directly to the brain, it had the same effect on appetite as a larger dose injected into the bloodstream.

NAPE concentrated in the hypothalamus, an important brain structure known to regulate hunger, and inhibited neurons that stimulate appetite, they said.

When the rodents were given extra NAPE for five days, they animals ate less and lost weight, the researchers said.

With obesity on the rise in many parts of the world as people eat fattier diets and get less exercise, scientists are eager to find new ways to combat the problem. These findings could help guide efforts to create better drugs to suppress appetite and reduce obesity, the researchers said.

"Clearly what we have in mind is trying to find new approaches that regulate food intake. And this may be a new pathway that one could target to treat obesity," Shulman said in a telephone interview.

"We're now doing the fat-feeding studies in humans to see if we get a similar increase in plasma (blood) NAPE concentrations following a fatty meal," Shulman added.

Scientists are working toward a greater understanding of how the body tells the brain to control food intake. Hormones such as leptin that help regulate this system have proven disappointing when examined as human weight-loss treatments.

(Editing by David Wiessler)

243 comments:

1 – 200 of 243   Newer›   Newest»
Anonymous said...

tramadol 50mg buy tramadol pharmacy - buy tramadol online no prescription cheap

Anonymous said...

buy tramadol saturday delivery buy tramadol 200mg online - tramadol withdrawal plan

Anonymous said...

buy generic tramadol help for tramadol addiction - tramadol withdrawal after 3 weeks

Anonymous said...

ativan drug ativan overdose level - ativan stopping use of

Anonymous said...

buy tramadol 100mg tramadol dosage drops - tramadol ingredients 50 mg

Anonymous said...

tramadol online pharmacy tramadol buy online - tramadol medication online

Anonymous said...

buy ativan ativan janice dickinson - ativan withdrawal long does take

Anonymous said...

ativan online ativan online - ativan juice

Anonymous said...

buy tramadol with paypal tramadol qt - tramadol dose get high

Anonymous said...

buy tramadol get tramadol online - buy tramadol cod

Anonymous said...

buy tramadol tramadol 37.5/325 dosage - buy tramadol 50mg online

Anonymous said...

buy tramadol medication tramadol hcl long term effects - tramadol zanaflex

Anonymous said...

tramadol online tramadol hcl capsules 50mg - tramadol dosage for high

Anonymous said...

buy ambien online ambien zolpidem addiction - ambien vicodin overdose

Anonymous said...

buy tramadol online no prescription cod tramadol 50mg ndc - tramadol opiate

Anonymous said...

buy generic klonopin klonopin withdrawal timeline - .5 klonopin and alcohol

Anonymous said...

buy tramadol with mastercard is ordering tramadol online illegal - tramadol hcl espanol

Anonymous said...

buy zolpidem online ambien high blood pressure - ambien cr snort

Anonymous said...

buy soma online buy soma online credit card - watch deadly soma 2 online

Anonymous said...

klonopin without prescription high from klonopin - buy rivotril clonazepam

Anonymous said...

buy ambien ambien dosage for kids - scary ambien stories

Anonymous said...

order tramadol online tramadol 50mg how much - buy-tramadol-online.org

Anonymous said...

soma online soma drug get high - generic soma medication

Anonymous said...

buy generic tramadol no prescription tramadol and vicodin - tramadol not working

Anonymous said...

buy ambien online ambien for pregnant women - buy cheapest ambien online

Anonymous said...

klonopin online klonopin overdose toddler - types generic klonopin

Anonymous said...

buy tramadol no prescription tramadol hcl 50 high - buy tramadol pay with mastercard

Anonymous said...

buy tramadol how to order tramadol - tramadol hcl 200 er

Anonymous said...

where can i buy ambien online zolpidem er generic ambien cr - ambien side effects shaking

Anonymous said...

soma online soma online radio - generic soma pill identification

Anonymous said...

klonopin antidepressant klonopin withdrawal weight gain - klonopin drug

Anonymous said...

tramadol online online apotheke holland tramadol - tramadol dose bluelight

Anonymous said...

ambien online without rx ambien side effects rash - ambien side effects rash

Anonymous said...

ambien cheap buy ambien overnight delivery - ambien no prescription cheap

Anonymous said...

generic carisoprodol soma rx - soma strongest muscle relaxer

Anonymous said...

buy tramadol for dogs buy tramadol ultram ultracet online - tramadol 100 mg slow release

Anonymous said...

buy klonopin online overnight ativan or klonopin for anxiety - klonopin and breastfeeding

Anonymous said...

buy generic tramadol online tramadol 50 dosage - buy tramadol cod

Anonymous said...

ambien pill will ambien show on a drug test - many ambien 10 mg get high

Anonymous said...

ambien cr ambien side effects depression - ambien long term

Anonymous said...

ativan pharmacy ativan how does it work - ativan dosage information

Anonymous said...

generic ambien buy ambien cr 240 coupon - insomnia ambien won't work

Anonymous said...

order tramadol online cod tramadol hcl online - buy tramadol safely

Anonymous said...

buy klonopin online 2mg clonazepam klonopin - klonopin peak

Anonymous said...

buy tramadol tramadol 200 mg high - buy tramadol usa

Anonymous said...

buy ambien online ambien cr cost per pill - scary ambien stories

Anonymous said...

buy tramadol online order tramadol for pets - tramadol jaw clenching

Anonymous said...

buy ambien online legally ambien cr generic side effects - buy cheapest ambien online

Anonymous said...

carisoprodol without prescription buy soma saturday delivery - generic soma dosage

Anonymous said...

klonopin mg klonopin withdrawal stomach pain - klonopin 1mg dosage

Anonymous said...

can you order viagra online how can i order female viagra online - lloyds pharmacy online viagra

Anonymous said...

buy tramadol cod next day delivery tramadol high energy - order tramadol online international

Anonymous said...

buy tramadol cash on delivery tramadol 100mg online - tramadol online florida

Anonymous said...

ambien no prescription ambien online - ambien side effects heart palpitations

Anonymous said...

ambien online no prescription ambien drug overdose - ambien cr 50 mg

Anonymous said...

how to buy viagra online how to buy viagra canada - viagra buy paypal

Anonymous said...

order soma online buy soma boardbag - soma online order

Anonymous said...

buy cheap viagra no prescription cheap viagra cialis india - cheap viagra online canada

Anonymous said...

buy tramadol online tramadol yahoo answers - tramadol zoloft together

Anonymous said...

generic tramadol online tramadol 50mg prescribed - buy generic tramadol

Anonymous said...

ambien online without rx ambien side effects memory - ambien sale mexico

Anonymous said...

klonopin online klonopin 6mg - how long do klonopin side effects last

Anonymous said...

ambien on line ambien is what class drug - will ambien show up hair drug test

Anonymous said...

buy generic tramadol tramadol information - tramadol 50mg uk

Anonymous said...

buy zolpidem online ambien cost cvs - ambience mall gurgaon closed tuesday

Anonymous said...

buy klonopin online no prescription klonopin withdrawal relief - klonopin 0.5mg

Anonymous said...

soma pain soma for muscle relaxation - soma gym

Anonymous said...

buy tramadol tramadol online missouri - tramadol hcl neuropathy

Anonymous said...

buy ambien online what does generic ambien cr look like - ambien drug side effects

Anonymous said...

ambien online pharmacy buy real ambien online - generic ambien 10mg 30 pills reviews

Anonymous said...

is it safe to order viagra online cheap generic viagra canada - can you buy viagra online in canada

Anonymous said...

buy tramadol online cheap tramadol purchase canada - tramadol hcl tab 200mg

Anonymous said...

buy klonopin online cheap klonopin wafers 2mg - buy klonopin with no prescription

Anonymous said...

tramadol online tramadol dosage by weight - tramadol hcl breastfeeding

Anonymous said...

ambien for sale online ambience mall gurgaon movies - cost ambien vs generic

Anonymous said...

generic ambien ambien cr half life - ambien cr 12.5 erowid

Anonymous said...

buy viagra los angeles viagra online discount - is generic viagra just as good

Anonymous said...

online soma soma 350 mg erowid - soma muscle relaxer alcohol

Anonymous said...

buy viagra online without rx is it legal to order viagra online in australia - can you buy viagra online in canada

Anonymous said...

sildenafil tablets buy generic viagra toronto - viagra risks

Anonymous said...

order generic viagra legal order viagra online canada - purchase viagra spain

Anonymous said...

buy viagra for women buy viagra fast shipping - how to purchase viagra online

Anonymous said...

soma price order soma drug - 350 mg of soma

Anonymous said...

cialis medication buy cialis online in nz - buy cialis online discount

Anonymous said...

order viagra online overnight buy viagra hua hin - united states online pharmacy viagra

Anonymous said...

buy viagra buy viagra online low price - buy viagra online with no prescription

Anonymous said...

order viagra online viagra zinc - buy viagra 100mg online uk

Anonymous said...

cheap generic cialis buying cialis online canada - 36 hour cialis online

Anonymous said...

propecia drug cheap finasteride - buy propecia toronto

Anonymous said...

buy cialis online cheap cialis online rx - cheap cialis professional

Anonymous said...

viagra online can i buy viagra online legally - cheap 25 mg viagra

Anonymous said...

buy propecia online generic finasteride good propecia - propecia side effects depression

Anonymous said...

tramadol online pharmacy tramadol normal dosage - tramadol hcl 50 mg tab dosage

Anonymous said...

cialis online cialis цени - generic cialis goedkoop

Anonymous said...

buy propecia online propecia mg - generic equivalent to propecia

Anonymous said...

viagra for sale generic viagra 100mg manufacturers - safest place buy viagra online

Anonymous said...

buy tramadol online generic tramadol - where to buy tramadol online safely

Anonymous said...

buy tramadol cod next day delivery buy tramadol online with mastercard - buy tramadol online with credit card

Anonymous said...

buy tramadol overnight shipping tramadol 325 mg high - buy tramadol online paypal

Anonymous said...

tramadol 50 tramadol for dogs addiction - tramadol hydrochloride 50mg tablets

Anonymous said...

buy tramadol online buy tramadol online overnight fedex - tramadol for dogs no rx

Anonymous said...

tramadol 50 mg tramadol hcl drug test - tramadol hcl er dosage

Anonymous said...

buy tramadol online buy tramadol cod fedex - tramadol hcl 37.5 mg

Anonymous said...

order tramadol online cod tramadol for back pain - tramadol legal to buy online

Anonymous said...

order tramadol where can i purchase tramadol with a mastercard - buy tramadol canada

Anonymous said...

where to buy tramadol buy tramadol order cheap tramadol online - tramadol online overnight saturday delivery

Anonymous said...

tramadol online tramadol hcl what is it for - tramadol hydrochloride dosage

Anonymous said...

buy tramadol online buy tramadol online no prescription cod - buying tramadol online illegal

Anonymous said...

tramadol no prescription tramadol over the counter - buy tramadol mexico

Anonymous said...

buy tramadol overnight buy cheap tramadol usa - buy tramadol online us pharmacy

Anonymous said...

tramadol 50mg tramadol hcl 325 mg - is tramadol for dogs an nsaid

Anonymous said...

buy propecia online propecia generic best price - propecia 1 year results

Anonymous said...

buy tramadol india tramadol dosage and administration - tramadol hcl urine drug test

Anonymous said...

buy tramadol online tramadol for dogs max dose - buy tramadol overnight shipping

Anonymous said...

tramadol online tramadol zoloft taken together - tramadol hcl 200mg er

Anonymous said...

cheap tramadol tramadol 93 58 side effects - tramadol 50 mg espanol

Anonymous said...

buy propecia online propecia results after 8 months - propecia hair growth reviews

Anonymous said...

tramadol 50 mg buy tramadol online reviews - buy tramadol online mastercard overnight

Anonymous said...

order retin-a buy retin a cheap - retin a no prescription needed

Anonymous said...

buy tramadol india can tramadol hcl 50 mg be cut in half - tramadol de 50 mg para que sirve

Anonymous said...

tramadol 50mg tramadol for dogs an 627 - tramadol hcl how to take it

Anonymous said...

tramadol online no prescription tramadol 1a pharma 50 mg - tramadol hcl 50 mg picture

Anonymous said...

tramadol online no prescription tramadol hcl msds - tramadol online with no prescription

Anonymous said...

tramadol 50mg tramadol 1 hcl 50mg - tramadol take get high

Anonymous said...

buy tramadol overnight shipping cheap tramadol/pharmacy - tramadol addiction treatment

Anonymous said...

buy tramadol tramadol 37.5 high - tramadol rash

Anonymous said...

viagra online pharmacy generic herbal viagra - order viagra with no prescription

Anonymous said...

generic viagra buy viagra pay with paypal - buy-viagra-online-50mg

Anonymous said...

purchase viagra how to order viagra online in us - order viagra men

Anonymous said...

tramadol online pharmacy can you buy tramadol in greece - tramadol for cats

Anonymous said...

viagra online without prescription viagra for women with antidepressants - viagra online purchase

Anonymous said...

buy tramadol tramadol hcl paracetamol tablets - tramadol dosage an 627

Anonymous said...

generic viagra viagra buy in tesco - buy viagra online pakistan

Anonymous said...

buy tramadol what dosage of tramadol should i take - tramadol 250 mg

Anonymous said...

cialis price illegal to buy cialis online - cialis tablet price

Anonymous said...

buy tramadol tramadol online pharmacy no prescription needed - tramadol hcl hcl

Anonymous said...

viagra online without prescription buy viagra online in nz - viagra online usn pharmacy

Anonymous said...

viagra online without prescription order viagra generic - viagra online us next day delivery

Anonymous said...

buy cialis generic cialis risks - buy cialis online yahoo

Anonymous said...

buy generic viagra viagra online hong kong - buy viagra online abroad

Anonymous said...

generic viagra buy viagra sample pack - buy viagra at walmart

Anonymous said...

discount viagra viagra online us no prescription - buy viagra cheap online us

Anonymous said...

buy tramadol buy tramadol online no prescription next day delivery - pill max order tramadol ultram online

Anonymous said...

cheap viagra online cheap viagra scams - buy viagra for men

Anonymous said...

generic cialis price quote+cialis - where to buy cialis in toronto canada

Anonymous said...

viagra no prescription buy viagra online us - buy viagra xanax

Anonymous said...

cheap viagra cheap brand viagra online - viagra+where to buy in melbourne

Anonymous said...

cialis online no prescription buy cialis online in canada - cialis viagra best price

Anonymous said...

generic viagra online cheap viagra usa - viagra for women over the counter

Anonymous said...

tadalafil online cialis 20 mg daily use - safe place order cialis

Anonymous said...

cheap cialis online cialis daily headache - generic cialis work

Anonymous said...

viagra online safest place order viagra - where to buy viagra online with no prescription

Anonymous said...

cialis cost cialis patent - buy cialis online with paypal

Anonymous said...

cialis tadalafil buy cialis in usa - cialis 800mg reviews

Anonymous said...

generic cialis cialis daily dose price - cialis with food

Anonymous said...

soma buy jogo de soma online - expired soma medication

Anonymous said...

soma no prescription buy somatropin online - soma zo seatpost

Anonymous said...

cialis online canada buy cialis online - generic cialis 200mg

Anonymous said...

buy cialis cialis black review - cialis kidney pain

Anonymous said...

buy cialis online cheap daily use of cialis - buy cialis online usa

Anonymous said...

buy soma online no prescription soma xanax - aura soma online reading

Anonymous said...

buy soma online soma online legal - soma 350 mg ingredients

Anonymous said...

viagra online cheap generic viagra online review - viagra online overnight

Anonymous said...

soma pharmacy radiohead soma san diego - buy generic soma online

Anonymous said...

tadalafil online cialis 20mg price us - cialis online singapore

Anonymous said...

buy soma cost cab sfo soma - can order soma online legally

Anonymous said...

buy soma soma pills weed - buy soma online ship texas

Anonymous said...

buy soma online generic soma with codeine - what are some pills

Anonymous said...

buy soma online buy soma rush frame - how to order soma online

Anonymous said...

purchase soma buy soma drink - soma 350 mg prescribed

Anonymous said...

buy soma online generic soma pill identifier - soma drug classification

Anonymous said...

soma muscle relaxant buy soma online + usa - do soma bras run big

Anonymous said...

order soma soma food trucks - soma puzzle

Anonymous said...

soma drug soma health club - order soma without rx

Anonymous said...

order soma online soma pills for sale - soma triathlon 2011 results

Anonymous said...

buy soma soma drug vault - get soma online

Anonymous said...

buy retin a cream retin-a cream vs. retin-a micro gel - purchase retin a .1

Anonymous said...

buy soma online soma 250 pill - muscle relaxer similar to soma

Anonymous said...

buy soma online ambien plus soma pharmacy - generic of soma

Anonymous said...

buy soma much does soma cost - generic soma 350

Anonymous said...

somas online soma drug reactions - soma 50 off coupon

Anonymous said...

soma online information on soma pills - watch deadly soma 2 online

Anonymous said...

soma online cheapest soma online - somo 650 user manual

Anonymous said...

soma online soma drug usa - buy qualitest soma online

Anonymous said...

buy soma online soma drug testing urine - buy soma in georgia

Anonymous said...

soma pills soma juice sale - buy somatropin 191aa

Anonymous said...

buy retin-a online retin a cream 0.025 - buy retin a 0.05 online pharmacy

Anonymous said...

order soma order soma online overnight delivery - buy generic soma no prescription

Anonymous said...

buy tramadol without a script tramadol online prescription - tramadol hcl monograph

Anonymous said...

tramadol online tramadol withdrawal symptoms - tramadol hcl 50 mg para que es

Anonymous said...

buy tramadol online tramadol for dogs 50 mg - tramadol 50mg side effects for dogs

Anonymous said...

tramadol 50 mg buy tramadol online pay cod - tramadol hcl 25mg dogs

Anonymous said...

buy tramadol best place buy tramadol online - cheap tramadol online cod

Anonymous said...

buy tramadol buy tramadol online no prescription cheap - tramadol 50 mg how many get high

Anonymous said...

retin a order online retin a cream 2 - retin a cream wrinkle treatment

Anonymous said...

tramadol online cod tramadol qt interval - order tramadol with saturday delivery

Anonymous said...

buy tramadol tablets tramadol hcl withdrawal symptoms - buy tramadol online cheap no prescription

Anonymous said...

buy tramadol ultram buy tramadol cod personal check - tramadol kick in time

Anonymous said...

buy retin a retin-a before and after acne - retin-a walmart

Anonymous said...

tramadol generic tramadol withdrawal no energy - buy tramadol 99

«Oldest ‹Older   1 – 200 of 243   Newer› Newest»