It can reduce the risk of HIV-infected people falling sick with TB.
A new Tuberculosis vaccine that can reduce the risk of HIV-infected people falling sick with TB, has been developed by a U.S. National Institutes of Health-sponsored trial in Dar-es-Salaam. Announcing the results of the ‘Dar Dar’ trial of the prime boost Mycobacterium vaccae (MV) vaccine at the 39th Union World Conference on Lung Health in Paris recently, Executive Director of the International Union Against TB and Lung Diseases (IUATLD) Nils Billo said the re sults were among “the most exciting and promising for people living with HIV in recent times.”
The trial was a collaboration between the Muhimbili University of Health and Allied Sciences in Tanzania and the U.S. Dartmouth Medical School (DMS) and cited by the investigators as a fine example of North-South cooperation in responding to an international health problem.
The seven-year study enrolled about 2,000 HIV positive volunteers who had received childhood BCG and whose CD4 count was 200 or more cells per microlitre of blood. The CD4 is a white blood cell that plays a critical role in the immune response and is normally above 800 cells per microlitre. Half the volunteers received five doses of the Mycobacterium vaccae two months apart over a year. The other half acted as a control arm receiving a dummy vaccine or placebo. Dr. Ford von Reyn, Professor of Medicine, DMS and principal investigator of the study said, “the vaccine was found to boost lymphocyte counts and protect against all forms of definite TB among 20 of the 1,000 who received it. There is no risk of getting TB infection from the vaccine itself as it is an inactivated form. The technology used to create the vaccine is low cost and that will help ensure its affordability in those countries where it will be needed most.”
TB is the world’s leading cause of death among PLHIV. Over a third of the global total of 33 million PLHIV is co-infected with TB and will likely die without treatment. One in five people with a severely weakened immune system can develop active TB within a year, an extraordinarily high risk. The risk of TB goes up as immunity comes down.
Preventing HIV positive people from falling sick with TB ranks among the leading public health challenges in China, India and the countries of sub-Saharan Africa. People whose immunity is down because of HIV infection, can have TB that manifests in a very atypical way, for example, without a persistent cough. Such people miss getting diagnosed with TB at the health care services and can die as a result. If cases of TB among PLHIV are diagnosed, the chance of them getting cured of TB is much worse than among those without HIV infection. In Malawi, for instance, four out of ten TB patients with HIV co infection die before the completion of anti-TB treatment. People who complete anti-TB treatment and are pronounced fully cured of TB run a high risk of getting TB again, owing to their low immunity.
A TB vaccine that will afford permanent protection is badly needed. It is too early to know if the Mycobaterium vaccae vaccine can do that. “Our follow-up with the study volunteers shows that the vaccine is affording a 40 per cent protection so far in these three to four years. We need to study its durability,” observed Dr. Robert Horsburgh, Chairman, Department of Epidemiology, Boston University Department of Public Health.
It is clear that the M.vaccae vaccine will have a profound impact on TB control among PLHIV in India as elsewhere. Dr. Anthony Harries, Senior Adviser to the IUATLD said, “these results suggest that about 6,000 cases of TB can be averted among a population of 2 million PLHIV within three years if 50 per cent of them received it.” The current armamentarium to prevent TB consists of the BCG vaccine which is given to children at birth. While it protects children from acquiring serious TB, it does not afford much protection to adults. Besides, BC being a live vaccine, could theoretically cause TB in PLHIV. The only other weapon available is giving HIV infected patients a daily dose of a single anti-TB drug — Isoniazid — to prevent them from getting TB. This measure is acknowledged to fuel the spread of Isoniazid resistant TB, but is still adopted as the lesser of the two evils. “The new vaccine would overcome both these challenges. I see it becoming part of a whole package of pre-Anti Retroviral Therapy care that can keep people with HIV healthy for many years,” said Prof. Harries. It is for future research to unravel how the vaccine may benefit people with CD4 counts lower than 200. While the Dar Dar study focused on a group at high risk for TB, the potential of the new vaccine to prevent TB among HIV negative individuals in TB prevalent areas is open to exploration. Meantime, it may be two years before Mycobacterium vaccae will become available.
Subscribe to: Post Comments (Atom)
If you're HIV+ like me, visit www.AIDSchat.org for a chat.
Wonderful blog! I found it while surfing around on Yahoo News.
Do you have any tips on how to get listed in Yahoo News? I've been trying for a while but I never seem to get there! Thanks
Feel free to visit my page - Abercrombie
I was suggested this website by my cousin. I'm not sure whether this post is written by him as nobody else know such detailed about my trouble. You are incredible! Thanks!
Stop by my blog Evgeni Malkin Black Jersey
I will immediately grasp your rss as I can not find your email subscription hyperlink or e-newsletter service.
Do you've any? Please permit me recognise so that I may subscribe. Thanks.
Review my webpage; Louis Vuitton Handbags Outlet
I really like what you guys are up too. Such clever work
and exposure! Keep up the great works guys I've added you guys to my blogroll.
Also visit my webpage: Abercrombie
Thank you for another informative blog. Where else may just I am getting
that kind of information written in such an ideal method?
I have a undertaking that I am simply now working on, and
I've been at the look out for such information.
My webpage - Sidney Crosby Black Jersey
Very nice post. I just stumbled upon your weblog and wanted to say that I
have really enjoyed browsing your blog posts.
In any case I will be subscribing to your rss feed and I
hope you write again very soon!
Also visit my weblog ... Sac A Main Louis Vuitton
Pretty! This has been an incredibly wonderful post.
Many thanks for providing these details.
Check out my weblog; Louis Vuitton Outlet
I know this web site gives quality depending articles and additional material,
is there any other website which provides these kinds of information in quality?
My website ... Abercrombie France
I would like to thank you for the efforts you have put in penning this website.
I am hoping to view the same high-grade content by you later on as well.
In truth, your creative writing abilities has motivated me to get my own,
personal site now ;)
my website - Sidney Crosby Black Jersey
Definitely believe that which you stated. Your favorite justification appeared to be on the
net the easiest thing to be aware of. I say to you, I definitely get annoyed while people think about worries that
they plainly don't know about. You managed to hit the nail upon the top as well as defined out the whole thing without having side-effects , people could take a signal. Will likely be back to get more. Thanks
My web site - Full Report
Pretty element of content. I simply stumbled upon your web site and in accession capital to assert that I acquire actually loved
account your weblog posts. Any way I'll be subscribing in your feeds or even I fulfillment you get admission to constantly rapidly.
My blog http://www.earlylearningpreschool.com/
all the time i used to read smaller posts which as well clear their motive, and that is also happening with this piece of writing which I am reading at this time.
My blog; Sac Louis Vuitton Pas Cher
Thank you for another excellent article. The place else could anybody get that
kind of info in such a perfect means of writing? I've a presentation subsequent week, and I'm at the look for such information.
Also visit my web blog: Cheap NFL Jerseys
I was wondering if you ever thought of changing the layout of
your website? Its very well written; I love what youve got to say.
But maybe you could a little more in the way of content
so people could connect with it better. Youve got an awful
lot of text for only having one or 2 images. Maybe you could space it out better?
My web blog: Christian Louboutin UK
I think the admin of this website is in fact working hard for his
site, as here every stuff is quality based stuff.
Also visit my weblog ... This Site ()
naturally like your website but you have to take a look at the spelling on quite a few of your
posts. A number of them are rife with spelling problems and I in finding it very troublesome to
inform the reality however I will surely come again again.
Here is my website; selling beats
It's amazing to pay a visit this site and reading the views of all mates regarding this article, while I am also keen of getting knowledge.
Also visit my web-site :: Cheap NFL Jerseys
Hi there are using Wordpress for your blog platform?
I'm new to the blog world but I'm trying to get started and set up my own.
Do you need any html coding knowledge to make your own blog?
Any help would be greatly appreciated!
My homepage ... Boutique Guess
Definitely believe that which you stated.
Your favorite reason appeared to be on the net the easiest thing to be aware of.
I say to you, I definitely get irked while people consider worries
that they just do not know about. You managed to hit the nail upon the top and defined out the whole thing without
having side-effects , people could take a signal. Will probably be back to get more.
Also visit my web blog Louis Vuitton ()
Hi there! I know this is kind of off topic but I was
wondering which blog platform are you using for this website?
I'm getting tired of Wordpress because I've had issues with hackers
and I'm looking at alternatives for another platform. I would be great if you could point me in the direction of a good platform.
Also visit my web-site: Louis Vuitton Pas Cher
You really make it appear so easy together with your presentation however I
to find this topic to be really one thing that
I believe I'd never understand. It seems too complicated and extremely wide for me. I'm
looking ahead for your next submit, I'll try to get the hold of it!
My web page Air Max
Pretty! This has been an extremely wonderful post.
Thanks for providing these details.
Also visit my web page - Borse Di Gucci
Great article, totally what I was looking for.
Visit my web-site - Air Max 1
What i don't understood is if truth be told how you are not actually a lot more well-liked than you may be right now. You are very intelligent. You realize thus considerably when it comes to this topic, made me in my view believe it from so many numerous angles. Its like women and men aren't involved except
it is something to do with Girl gaga! Your individual
stuffs nice. Always handle it up!
my site ... Learn More Here
You actually make it seem so easy with your presentation but I find this topic
to be actually something which I think I would never understand.
It seems too complex and extremely broad for me. I'm looking forward for your next post, I'll try to get the hang of
My weblog Nike UK
HERBAL MEDICINE FOR HIV.
To all HIV patients out there, Impossible situations is becoming possible miracles gradually, It might help you too. This medicine works perfectly for me. I suffered HIV for 5 years. I had no idea what was happening and didn’t know where to turn for help. It was hard then because I really didn’t understand the symptoms earlier until I was diagnosed. The anguish I went through taking care of myself alone is beyond explanation because there was no support of whatsoever from family members. I fought for proper medical care and humane treatment; I did everything within my reach to get cured but all to no avail. Countless different medications was prescribed antiretroviral therapy (Zidovudine, azidothymidine, Stavudine, Risperdal, quetiapine, etc.) that I was taking but all I could get was myriad of side effects such as rigidity, drowsiness, dizziness, tremors and restlessness which tends to worsen the already damaged situation. Frustration was the order of the day.
At the foundation someone shared a testimony about herbal medicine, how effective it is and how she went through the most difficult times of her life trying to help her mom fight HIV. Being that I was already at the verge of giving up because I just couldn't imagine waking up every morning to fight the same thing that left me so tired the night before. I had to contact the doctor, from our conversation; I was relieved and convinced that the result is going to be positive because I was made to contact people with worse cases. Today, the awful situation has gone by. My happy life is back. I'm now HIV survivor and I am glad because my daily routine activities had now kick off without obstructions. Don't let HIV hinder you from living a desired life and also, never allow anyone decide for you especially when they don't know what you have to go through to get to where you are. I was almost discouraged by the doctor but then, I remembered that: I have to shield my destiny with courage, faith and perseverance my life is now a testimony. After I got cured, I said, Mom “I just thought, ‘Well, I’m a unconventional, I’ll never be normal, then she said, my daughter, life itself is a misery and we get stronger in the places we have been broken. Thanks to you Dr. Aparajita for your excellent counseling, no more HIV symptoms for the past 3 years and 2 months now. To know more about Dr. Aparajita and the effectiveness of his Herbs, You can reach him via: firstname.lastname@example.org. I believe you will testify just like me.
Post a Comment